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KMID : 0043320100330010067
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Archives of Pharmacal Research
2010 Volume.33 No. 1 p.67 ~ p.70
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Tribuli Fructus Constituents Protect against Tacrine-Induced Cytotoxicity in HepG2 Cells
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Kim Youn-Chul
Jeong Gil-Saeng
Min Tae-Sun
An Ren-Bo
Byun Erisa
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Abstract
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A new phenolic amide, tribulusimide D (4-hydroxy-N-[3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-methoxybenzamide) (1), together with a known phenolic amide, terrestriamide ((E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)-2-oxoethyl]-prop-2-enamide) (2) and a flavonol glycoside, quercetin-3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (3) were isolated from the H2O extract of Tribuli Fructus. Compounds 1 and 3 showed significant hepatoprotective activities, with EC50 values of 13.46 ± 0.2 and 7.06 ± 0.7 μM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
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